The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
申请公布号
EP2163260(A2)
申请公布日期
2010.03.17
申请号
EP20090176105
申请日期
2005.01.18
申请人
ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
发明人
CIRILLO, AGOSTINO;COLLOCA, STEFANO;ERCOLE, BRUNO BRUNI;MEOLA, ANNALISA;NICOSIA, ALFREDA;SPORENO, ELISABETTA