NEW PREPARATION OF HYDROXYCHLOROQUINE

摘要

PURPOSE: A method for preparing hydroxychloroquine is provided to suppress generation of by-product by reducing reaction temperature and time and prepare the hydroxychloroquine with high yield and purity. CONSTITUTION: A hydroxychloroquine of chemical formula 1 is prepared by reacting N'ethyl-N' β-hydroxyethyl-1,4-pentadiamine with 4,7-dichloroquinoline at high pressure. The high pressure is over 5bar. The reaction condition is 100-120°C for six hours. A method for preparing hydroxychloroquine sulfate comprises: a step of reacting N'ethyl-N' β-hydroxyethyl-1,4-pentadiamine with 4,7-dichloroquinoline to obtain hydroxychloroquine; and a step of reacting sulfuric acid with hydroxychloroquine to obtain hydroxychloroquine sulfate.