发明名称 |
Viral vectors expressing fusion of viral large envelope protein and protein of interest |
摘要 |
The present invention provides a virus-like particle (VLP) comprising i) a polypeptide comprising a polypeptide of interest (POI) and at least a particle-associating portion of a large envelope (L) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof, and ii) a small envelope (S) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof. By introducing one or more POIs into the L polypeptide, the POI is translocated along with L into a particle structure made up primarily of S polypeptide. The present invention furthermore provides methods for producing a recombinant virus-like particle.
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申请公布号 |
US7678374(B2) |
申请公布日期 |
2010.03.16 |
申请号 |
US20040553683 |
申请日期 |
2004.04.16 |
申请人 |
HEPGENICS PTY LTD |
发明人 |
ANDERSON DAVID ANDREW;GRGACIC ELIZABETH VERA LUDMILA |
分类号 |
A61K39/00;C07K14/00;C12N7/01;C12N7/04;C12N15/86 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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