发明名称 |
VERFAHREN ZUR ERZEUGUNG VON METALLCHELATAFFINITÄTSLIGANDEN |
摘要 |
The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of (a) providing at least one cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile; (b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities are protected, on each scaffold by derivatisation of the nucleophile of said scaffolds, while retaining the cyclic structure of the scaffold; (c) ring-opening at the bond between the carbonyl and the sulphur of the derivatised scaffold by adding a reagent that adds one or more metal chelating affinity ligand arms to the scaffold; and, if required, (d) deprotecting the functionalities of the ligand arm(s) provided in step (b). In the most preferred embodiment of the method, steps (c) and (d) are performed simultaneously as one single step. |
申请公布号 |
AT457993(T) |
申请公布日期 |
2010.03.15 |
申请号 |
AT20030816091T |
申请日期 |
2003.12.08 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
ANDERSSON, LARS;AXEN, ANDREAS;GEBRU, TESFAI;MALOISEL, JEAN-LUC;TEDEBARK, ULF |
分类号 |
C07K1/22;B01D15/38;B01J20/281;B01J45/00;C07C323/58;C07D333/36 |
主分类号 |
C07K1/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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