发明名称 |
ZWISCHENPRODUKT UND VERFAHREN ZUR HERSTELLUNG VON AN BETA-ANOMEREN ANGEREICHERTEN 2'-DESOXY,2',2'- DIFLUOR-D-RIBUFURANOSYLNUKLEOSIDEN |
摘要 |
<p>The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of beta-anomer enriched 2<SUP>1</SUP>-deoxy-2<SUP>1</SUP>,2<SUP>1</SUP>-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable salts thereof, in particular, the beta-enriched anomer of gemcitabine hydrochloride of formula (IIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I).</p> |
申请公布号 |
AT458743(T) |
申请公布日期 |
2010.03.15 |
申请号 |
AT20050794951T |
申请日期 |
2005.09.23 |
申请人 |
FRESENIUS KABI ONCOLOGY LIMITED |
发明人 |
MAIKAP, GOLAK CHANDRA;BHATT, DEEPENDRA;PANDA, BIJAN KUMAR |
分类号 |
C07H13/08;C07H19/073 |
主分类号 |
C07H13/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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