RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END
摘要
The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5'? 3' directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
申请公布号
WO2010027512(A2)
申请公布日期
2010.03.11
申请号
WO2009US05063
申请日期
2009.09.08
申请人
CHEMGENES CORPORATION;SRIVASTAVA, SURESH, C.;PANDEY, DIVYA;SRIVASTAVA, NAVEEN, P.;BAJPAI, SATYA, P.
发明人
SRIVASTAVA, SURESH, C.;PANDEY, DIVYA;SRIVASTAVA, NAVEEN, P.;BAJPAI, SATYA, P.