发明名称 |
COMBINATION THERAPY FOR TUBERCULOSIS |
摘要 |
The present invention relates to methods of treating tuberculosis, including multi¬ drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (I), (S)-N- [[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. The present invention also relates to a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, (ii) a therapeutically effective amount of at least one agent useful in the treatment of tuberculosis and (iii) one or more pharmaceutically acceptable carriers or vehicles. |
申请公布号 |
CA2735229(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
CA20092735229 |
申请日期 |
2009.08.31 |
申请人 |
PFIZER INC.;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
BRICKNER, STEVEN JOSEPH;NUERMBERGER, ERIC;STOVER, CHARLES KENDALL |
分类号 |
A61K31/541;A61K31/4409;A61K31/496;A61K31/4965;A61P31/06 |
主分类号 |
A61K31/541 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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