发明名称 |
Compositions and methods to modulate an immune response to an immunogenic therapeutic agent |
摘要 |
Methods and compositions for modulating an immune response to an immunogenic therapeutic agent are disclosed. One of the disclosed methods comprises administering an effective amount of CTLA-4 to decrease the incidence of an immune reaction in conjunction with the administration of a potentially immunogenic substance. Another method contemplates tolerizing a subject to a therapeutic molecule that is or is capable of being immunogenic by the administration of CTLA-4. Various embodiments of CTLA-4 are also disclosed. |
申请公布号 |
AU2004287431(B2) |
申请公布日期 |
2010.03.11 |
申请号 |
AU20040287431 |
申请日期 |
2004.10.26 |
申请人 |
AMGEN INC. |
发明人 |
ULRICH FEIGE;SANJAY D. KHARE |
分类号 |
A61K38/17;A61K;A61K38/19;A61K39/395 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|