发明名称 |
MUTATED NETRIN-4 PROTEINS, FRAGMENTS THEREOF AND THEIR USES AS DRUGS |
摘要 |
The present invention relates to a mutated protein comprising or consisting of the sequence of wild type netrin 4, represented by SEQ ID NO : 2, wherein at least one amino acid of the amino acids at position (13, 68, 183, 205, 234, 331, 332, 353, 472, 515, 589, 625, 626, 627) and (628) is mutated enabling thus to confer 1 to 15 mutations to said wild type protein, or, truncated protein derived from said mutated protein, wherein the 19 first contiguous, or the 31 first contiguous amino acids at the N-terminus part of said mutated protein are deleted; and/or said mutated protein being deleted of all amino acids located after the amino acid in position (477) or of all amino acids located after the amino acid in position (515). |
申请公布号 |
WO2010007144(A3) |
申请公布日期 |
2010.03.11 |
申请号 |
WO2009EP59189 |
申请日期 |
2009.07.16 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;PLOUET, ISABELLE, CLARISSE, SOLANGE;PLOUET, CLAIRE, CHARLOTTE;PLOUET, ANNE, FLORENCE;LECONTE, LAURENCE;LEJMI, ESMA |
发明人 |
LECONTE, LAURENCE;LEJMI, ESMA;PLOUET, JEAN |
分类号 |
C07K14/475;A61K38/18;C07K16/22;C12N15/12 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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