发明名称 |
PROCESS FOR PREPARATION OF SOLID MONTELUKAST |
摘要 |
A process for preparation of montelukast or a salt thereof is provided, the process including reacting a late intermediate compound which is 2-[1-[1-R-3-[2-(7 chloro quinolin-2-yl)vinyl [phenyl]-3-[2-methoxy carbonyl phenyl]propyl sulfonyl methyl]cyclo propyl]acetic acid or a salt thereof with methyl magnesium chloride or methyl magnesium bromide in an organic solvent. In one embodiment, the process includes reacting an earlier intermediate compound which is methyl 2-(3-R-(3-(2-(7-chloro 2-quinolinyl)-ethenyl)-3 hydroxy propyl)benzoate with methane sulfonyl chloride or toluene sulfonyl chloride to obtain a mesylated or tosylated derivative of the earlier intermediate compound; followed by a reaction of the mesylated or tosylated derivative with 1-mercapto methyl cyclopropane acetic acid in a polar solvent in a presence of a base to obtain the late intermediate compound.
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申请公布号 |
US2010063291(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
US20090619736 |
申请日期 |
2009.11.17 |
申请人 |
DR. REDDY'S LABORATORIES, INC.;DR. REDDY'S LABORATORIES LIMITED |
发明人 |
REGURI BUCHI REDDY;BOLLIKONDA SATYANARAYANA;CHANDRA SEKHAR BULUSU VEERA VENKATA NAGA;KASTURI RAVI KUMAR;AAVULA SANJEEV KUMAR |
分类号 |
C07D215/14;C07D215/16;C07D215/18 |
主分类号 |
C07D215/14 |
代理机构 |
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主权项 |
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