ORAL DOSAGE FORMS OF LINEZOLID AND PROCESSES FOR THEIR PREPARATION

摘要

A high drug load spheronized beadlet is provided wherein, a core comprises Linezolid in 60 to 90 % by weight of dosage form; one or more binders selected from the group consisting of Carboxymethylcellulose sodium, Hydroxypropyl methylcellulose, Pregelatinized cornstarch in 0.2 to 10% by weight; and, one or more disintegrants selected from the group consisting of Sodium starch glycolate, Cross-linked sodium, Carboxy methylcellulose and Cross-linked polyvinyl pyrrolidone in 1 to 10% by weight. The pharmaceutical beadlet or pellet is manufacture by extrusion and spheronization method. The beadlet or pellet is manufactured, for example using Linezolid, Sodium Carboxy methylcellulose, sodium starch glycolate and magnesium stearate. The spheronized pellets or beadlet are manufactured into different pharmaceutically acceptable dosage forms.