发明名称 |
MODIFIED SOLUBLE FGF RECEPTOR FC FUSIONS WSITH IMPROVED BIOLOGICAL ACTIVITY |
摘要 |
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules. |
申请公布号 |
US2010061979(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
US20070515463 |
申请日期 |
2007.11.28 |
申请人 |
CENTELION |
发明人 |
BLANCHE FRANCIS;CAMERON BEATRICE;NESBIT MARK;SORDELLO SYLVIE;NICOLAZZI CELINE;TROMBE MARC |
分类号 |
A61K39/395;A61P35/00;A61P35/02;C07H21/04;C07K16/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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