发明名称 |
MATERIALS AND METHODS FOR INHIBITING CANCER CELL INVASION RELATED TO FGFR4 |
摘要 |
<p>The invention provides an isolated antibody or antibody fragment thereof that binds an extracellular epitope of a fibroblast growth factor receptor-4 (FGFR4) that is expressed by mammalian cells and inhibits cancer cell invasion. Optionally, the antibody or fragment thereof binds an epitope of FGFR4 that is bound by monoclonal antibody F90-10C5, or comprises complementarity determining regions identical to those of monoclonal antibody F90-10C5. Also provided are methods of using the antibody or fragment thereof to modulate invasion, ingrowth, or metastasis of cancer cells and treat cancer in a subject. The invention additionally provides a method of identifying an antibody or antibody fragment that inhibits invasiveness.</p> |
申请公布号 |
WO2010026291(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
WO2009FI50697 |
申请日期 |
2009.09.02 |
申请人 |
LICENTIA LTD.;ALITALO, KARI;LEHTI, KAISA;KESKI-OJA, JORMA;ALITALO, ANNAMARI |
发明人 |
ALITALO, KARI;LEHTI, KAISA;KESKI-OJA, JORMA;ALITALO, ANNAMARI |
分类号 |
C07K16/28;A61K38/10;A61K39/395;A61P35/00;C12N5/20;C12N15/12;C12N15/63 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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