PERCUTANEOUSLY ABSORBABLE PHARMACEUTICAL COMPOSITION OF OXYCODONE, PHARMACEUTICAL COMPOSITION STORAGE UNIT AND PERCUTANEOUSLY ABSORBABLE PREPARATION BY UTILIZING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a percutaneously absorbable pharmaceutical composition maintaining the blood concentration of oxycodone in an effective level over at least 48 hr on applying to a human.

SOLUTION: The percutaneously absorbable pharmaceutical composition prepared by blending an active ingredient selected from the oxycodone or its salts in an active ingredient-holding medium having fluidity at a temperature in the vicinity of a human skin surface temperature by a blending amount higher than its saturation solubility and holding at least a part of the active ingredient as a crystal form is characterized by making the preparation so that the percutaneously absorbable pharmaceutical composition has 31.1 mg content of the active ingredient based on the oxycodone base per one sheet and an effective percutaneous absorption range becomes as a square having 1.5 cm side, and showing at least≥150μg/hr/cm2mean permeation rate of the active ingredient based on the oxycodone base on applying it on the abdominal flawless skin of a hairless rat for 48 h.

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