发明名称 |
METHOD FOR INHIBITING SIGNAL TRANSDUCTION, SIGNAL TRANSDUCTION INHIBITOR TO BE USED THEREIN AND USE THEREOF |
摘要 |
An object of the present invention is to provide a method for inhibiting activation of signaling pathway mediated by erbB1 or erbB2 in human cell and a signaling inhibitor to be used therefor. The above-described activation of signaling pathway can be inhibited by a polypeptide comprising at least one of PTB domain or ERK2 binding domain of human FRS2β. The above-described polypeptide may be introduced directly into cell, or nucleic acid which encodes for the above-described polypeptide may be introduced into cell to allow expression of the polypeptide in the cell. Such polypeptide and nucleic acid can be used, for example, as a signaling inhibitor. In addition, since erbB1 and erbB2 are involved in development of cancer, the above-described signaling inhibitor is also useful, for example, as an anticancer drug.
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申请公布号 |
US2010062978(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
US20070294347 |
申请日期 |
2007.03.23 |
申请人 |
THE UNIVERSITY OF TOKYO;TOKYO MEDICAL UNIVERSITY;NATIONAL UNIVERSITY CORPORATION- TOKYO MEDICAL AND DENTAL UNIVERSITY |
发明人 |
GOTOH NORIKO;KURODA MASAHIKO;TSUCHIDA NOBUO |
分类号 |
A61K38/16;A61K31/7088;A61P35/00;C07H21/00;C07K7/08;C07K14/00;C12Q1/68 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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