| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for screening a new sodium-dependent bile acid transporter protein, an Na<SP>+</SP>/H<SP>+</SP>exchange transporter protein, a P-type ATPase protein and a vanilloid receptor protein, polynucleotides encoding these proteins, antisense polynucleotides thereof, antibodies thereof, and compounds promoting or inhibiting the activities of the proteins or compounds promoting or inhibiting expression of genes of the proteins, and to provide the compounds obtained from the method for screening. Ž<P>SOLUTION: The proteins are useful as diagnostic markers, etc., for example, for hyperlipemia, arteriosclerosis, genital diseases or digestive diseases; respiratory diseases, renal diseases or digestive diseases; pancreatic diseases, central nerve diseases, digestive diseases or respiratory diseases; inflammatory diseases, rheumatoid diseases or diabetic neurosis; etc., the compounds promoting or inhibiting the activities of the proteins obtained by the screening method utilizing the proteins are useful as preventives/remedies for the diseases. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
|
