发明名称 |
USE OF FIBRINOGEN AS A PROPHYLACTIC TREATMENT TO PREVENT BLEEDING DURING AND AFTER SURGERY AND AS A BIOMARKER TO IDENTIFY PATIENT WITH AN INCREASED RISK FOR EXCESSIVE BLEEDING AND BLOOD TRANSFUSION |
摘要 |
The present invention provides a method for preventing peri- and postoperative bleeding in subjects undergoing surgery, in particular subjects with a preoperative fibrinogen plasma level equal to or above the normal range. The method comprises administration of a substance with fibrinogen-like activity to the subject in an amount that result in a circulating fibrinogen plasma level of from about 1.0 g/L. The present invention also provides a method for determining the risk of subjects with a preoperative fibrinogen plasma level equal to or above the normal range to bleed postoperatively. Furthermore, the present invention provides means for predicting the necessity of blood or plasma transfusion after a subject with a preoperative fibrinogen plasma level equal to or above the normal range has been subject to a surgical procedure. The means involves measurement of the fibrinogen level of the subject before surgery and comparing the level with a risk curve.
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申请公布号 |
US2010062981(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
US20080525516 |
申请日期 |
2008.01.30 |
申请人 |
JEPPSSON ANDERS;SKRTIC STANKO;BRUCE LENNART;JOHNSSON JOERGEN;HEDNER THOMAS |
发明人 |
JEPPSSON ANDERS;SKRTIC STANKO;BRUCE LENNART;JOHNSSON JOERGEN;HEDNER THOMAS |
分类号 |
A61K38/36;A61P7/00;C12Q1/56 |
主分类号 |
A61K38/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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