发明名称 |
THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BASED ON THE ROLE OF THE CXCR-4 GENE IN TUMORIGENESIS |
摘要 |
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicant's surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype. |
申请公布号 |
US2010062003(A1) |
申请公布日期 |
2010.03.11 |
申请号 |
US20090367308 |
申请日期 |
2009.02.06 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
MURPHY GERALD P.;BOYNTON ALTON L.;SEHGAL ANIL;MURPHY BRIDGET |
分类号 |
A61K39/395;G01N33/53;A61K31/7088;A61K31/711;A61K38/00;A61K45/00;A61K48/00;A61P35/00;C07H21/00;C07H21/04;C07K14/715;C07K16/18;C07K16/24;C07K16/28;C07K16/32;C12N15/09;C12Q1/02;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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