FENTANYL COMPOSITION FOR NASAL ADMINISTRATION, METHOD FOR THE TREATMENT OF PAIN

摘要

The treatment of acute pain with a sufficient dosage by intranasal administration of fentanyl results in a time to onset of action comparable to intravenous administration and a significantly faster onset of action than nasal titration of fentanyl. The nasal administration of a sufficient amount of fentanyl to obtain pain relief has lower maximum plasma concentrations comparable to intravenous administration and results in lower rates of adverse events like respiratory depression, nausea and vomiting. Disclosed are use of a fentanyl salt for the preparation of a nasal spray or nasal drop formulation, a nasal spray or nasal drop formulation and a method for manufacturing thereof.