摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of modulating expression of a target gene induced by -catenin using an agent which increases linkage of p300 with -catenin and reduces linkage of CBP with -catenin, involving bringing a composition containing -catenin, CBP and p300, where -catenin is more likely linked to CBP than p300, into contact with an agent in an amount which is effective for changing the probability of linking -catenin to CBP compared to p300, where the said agent is a compound with a structure selected from formula (I), or its stereoisomers: where A represents -(C=O)-, B represents -(CHR4)-, D represents -(C=O)-, E represents -(ZR6)-, G represents -(XR7)n-> W represents (C=O)NH-, X represents nitrogen or CH, Z represents CH, n = 0 or 1. Values of substitutes R1 and R2 are indicated in the formula of invention. The invention also relates to a composition for modulating expression of a target gene induced by -catenin. ^ EFFECT: novel compounds have useful biological properties. ^ 9 cl, 7 tbl, 30 dwg, 7 ex |