METABOLICALLY ENGINEERED BACTERIAL STRAINS HAVING NON-FUNCTIONAL ENDOGENOUS GLUCONATE TRANSPORTERS
摘要
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
申请公布号
EP1625211(A4)
申请公布日期
2010.03.10
申请号
EP20040785902
申请日期
2004.05.10
申请人
GENENCOR INTERNATIONAL, INC.
发明人
DODGE, TIMOTHY, C.;VALLE, FERNANDO;KUMAR, MANOJ;RASHID, M., HARUNUR