摘要 |
PURPOSE: A sustained release table containing talniflumate is provided to enhance the solubility of non-soluble talniflumate and to control the release rate. CONSTITUTION: A talniflumate sustained release table contains talniflumate as an active ingredient, a solubilizer, and a hydrophilic polymer for a sustained release. The solubilizer is sodium laurylsulfate, taurodeoxycholic acid, cholic acid, chenodeoxycholic acid, ursodeoxycholic acid, Tween class or span class. The hydrophilic polymer is cellulose, polyalkyleneoxide, alginate, polyvinylalcohol, polyvinylpyrolidone, polyalckylglycol, polydextrin, pectin, povidone, carbomer, or Eudragit. The talniflumate sustained release tablet is formulated in a double-layer with a core tablet. The surface of the sustained release tablet also contains a drug coating layer coated with a drug coating solution. The drug coating liquid is polyvinyl alcohol, polypropyleneglycol, acrylic acid copolymer, hydroxylrpopyl methylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, or cellulose acetate.
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申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;KEUNWHA PHARMACEUTICAL CO., LTD. |
发明人 |
LEE, JUNG EUN;SHIN, BYUNG CHUL;CHO, SUN HANG;SEONG, HA SOO;AHN, SHIN BYOUNG;KWON, MU GIL;KIM, JONG TAEK |