发明名称 |
PHARMACEUTICAL COMPOSITION FOR APPETITE SUPPRESSION OR PREVENTION AND TREATMENT OF PSYCHIATRIC DISORDER, CONTAINING THE EXTRACT OF MORI FOLIUM, FRACTION THEREOF OR COMPOUND ISOLATED THEREFROM, HAVING MCH-1 RECEPTOR ANTAGONISTIC EFFECT, AS AN ACTIVE INGREDIENT |
摘要 |
PURPOSE: A composition containing Mori folium extract of a compound isolated from the same is provided to ensure antagonistic activity to Melanin Concentrating Hormone(MCH) and to control anxiety or depression. CONSTITUTION: A pharmaceutical composition for preventing and treating depression and suppressing appetite contains Mori folium fraction. A Mori folium fraction is obtained by extracting using alcohol, removing alcohol, suspending with distilled water, and fractioning dichlrodomethane, butanol or hexane. A method for preparing a compound of chemical formulas 1-6 comprises: a step 1 of adding alcohol to Mori folium to obtain Mori folium extract; a step of suspending the extract in water and fractioning with dichloromethane to obtain dichloromethane fraction a step of performing column chromatography to obtain active fraction; a step of performing column chromatography again to obtain active fraction; and a step of performing silica gel column chromatography to isolate a compound of chemical formulas 1-6.
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申请公布号 |
KR20100024897(A) |
申请公布日期 |
2010.03.08 |
申请号 |
KR20090075413 |
申请日期 |
2009.08.14 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
KIM, YOUNG SUP;RYU, SHI YONG;YON, GYU HWAN;HONG, KYUNG SIK;LEE, BYUNG HOI;CHOI, YEON HEE;CHOI, JAE SEOK;LEE, BYUNG HO;SEO, HO WON;OH, KWANG SEOK |
分类号 |
A61K31/409;A61K36/605;A61P3/04;A61P25/24 |
主分类号 |
A61K31/409 |
代理机构 |
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