发明名称 |
SCREENING METHOD FOR IDENTIFYING PATIENTS AT RISK OF ADVERSE HEPATOLOGIC EVENTS |
摘要 |
This present invention provides methods and kits for identifying patients at risk of suffering from a drug induced liver injury, particularly for an antioxidant drug, or for identifying patients who are suffering from early stages of a liver disorder by assessing the levels of apolipoprotein in a sample of the patient and comparing that to a reference value. The reference value is predetermined by identifying a population sample and determining an upper limit of normal value. This value is then used as a reference point for comparison of apolipoprotein levels from patient samples. In one embodiment, apolipoprotein levels are combined with ATL and/or total bilirubin levels for predicting liver damage, hepatotoxicity or hepatic events after drug administration.
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申请公布号 |
CA2735582(A1) |
申请公布日期 |
2010.03.04 |
申请号 |
CA20092735582 |
申请日期 |
2009.08.28 |
申请人 |
SALUTRIA PHARMACEUTICALS, LLC |
发明人 |
MEDFORD, RUSSELL;BOROW, KENNETH M.;MAIBACH, HILDA |
分类号 |
G01N33/68;A61P3/10;G01N33/15 |
主分类号 |
G01N33/68 |
代理机构 |
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地址 |
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