发明名称 |
HIV-1 ENVELOPE POLYPEPTIDES FOR HIV VACCINE |
摘要 |
<p>Immunogenic HIV-1 envelope polypeptides are provided, wherein specificamino acid residues are mutated to repress immunosuppression in GP41, thereby boosting the immune response against HIV-1. Specifically, mutation of those specific residues does not affect the fusogenic propertiesof the viral particleand/or the overall protein structure of the viral envelope protein.The invention further provides peptides and antigens based on the immunogenic HIV-1 envelopes as well as nucleic acid sequences and vectors encoding those. Moreover, biological entities such as viral particles are provided, as well as use of the provided components for preparation of a vaccine against HIV-1/AIDS.</p> |
申请公布号 |
CA2735278(A1) |
申请公布日期 |
2010.03.04 |
申请号 |
CA20092735278 |
申请日期 |
2009.08.28 |
申请人 |
AARHUS UNIVERSITET;REGION MIDTJYLLAND |
发明人 |
DUCH, MOGENS RYTTERGAARD;PEDERSEN, FINN SKOU;BAHRAMI, SHERVIN;FREDSTED, PALLE VILLESEN;WIUF, CARSTEN;OESTERGAARD, LARS JOERGEN;TOLSTRUP, MARTIN |
分类号 |
C07K14/16;A61K39/21;C07K16/10;C12N15/49 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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