发明名称 |
MUTANT BACTERIAL GLYCOPROTEINS AND USES THEREOF |
摘要 |
The present invention relates to the use of mutant glycoproteins from pathogenic bacteria lacking one or more phosphorylcholine and/or glycosylation post-translational modifications as immunogens. These post-translational modifications act as masking structures that elicit an immune response which does not confer protection on an infected individual. The removal or modification of these masking structures alters the protein such that it elicits a stronger immune response to the protein and/or the bacterial pathogen. Particular examples are pilin proteins and nitrite reductase glycoproteins of Neisseria bacteria. |
申请公布号 |
WO2010022462(A2) |
申请公布日期 |
2010.03.04 |
申请号 |
WO2009AU01111 |
申请日期 |
2009.08.28 |
申请人 |
THE UNIVERSITY OF QUEENSLAND;JENNINGS, MICHAEL, PAUL |
发明人 |
JENNINGS, MICHAEL, PAUL |
分类号 |
C07K14/195;C07K14/22 |
主分类号 |
C07K14/195 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|