发明名称 |
MR METHODS OF GRADING A TUMOR USING AN IMAGING MEDIUM THAT COMPRISES HYPERPOLARISED 13C-PYRUVATE |
摘要 |
The application relates to MR methods of grading a tumor using an imaging medium which comprises hyperpolarizedC-pyruvate. In particular, it relates to a method of determining the grade of a tumor, said method comprises a) MR detecting a tumor in a subject using an imaging medium that comprises hyperpolarizedC-pyruvate wherein signals ofC-pyruvate and itsC-containing metabolites alanine, lactate and optionally bicarbonate are detected; b) using said signals and optionally the total carbon signal to generate a metabolic profile of the tumor; c) comparing the metabolic profile of the tumor generated in step b) to a known metabolic profile of a tumor of a certain grade; and d) determining the grade of the tumor based on the similarities and differences between said metabolic profile of the tumor and said known metabolic profile.
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申请公布号 |
KR20100023802(A) |
申请公布日期 |
2010.03.04 |
申请号 |
KR20097023876 |
申请日期 |
2008.05.16 |
申请人 |
GENERAL ELECTRIC COMPANY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
HURD RALF EUGENE;KURHANEWICZ JOHN;VIGNERON DANIEL BLACKBURN;NELSON SARAH JANE |
分类号 |
G01N24/08;A61B5/055;G01N33/483 |
主分类号 |
G01N24/08 |
代理机构 |
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主权项 |
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地址 |
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