DEUTERATED IBUDILAST

摘要

This invention relates to novel compounds that are 2-alkyl-3-acylpyrazolo[l,5- a]pyridines, their derivatives, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to 2-alkyl-3-acylpyrazolo[l,5-a]pyridine compounds that are derivatives of ibudilast. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a phosphodiesterase (PDE) inhibitor, a leukotriene CysLTl (LTD4) antagonist, an inhibitor of nitric oxide synthase, and/or a glial cell activation suppressant, such as ibudilast.