PREPARATION OF ANGIOTENSIN IIAT1 RECEPTOR ANTAGONIST FORMULATION FOR TREATMENT OF ARTERIAL HYPERTENSION, OTHER CARDIOVASCULAR DISEASE AND THEIR COMPLICATION

摘要

PROBLEM TO BE SOLVED: To prepare AT1 receptor antagonist formulations using cyclodextrins, their derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular diseases and their complications. SOLUTION: Until now, no applications using the AT11receptor antagonists, cyclodextrins or derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular diseases and their complications, are found in the prior art. The invention is characterized by the combination of two different technologies: one is the molecular encapsulation of AT11receptor antagonists in cyclodextrins and the other is the microencapsulation in biodegradable polymers. The formulation also comprises the increase of the effectiveness of the AT11receptor antagonists as well as an increase in their bio-availability. The invention comprises a new more effective alternative for the treatment of arterial hypertension, other cardiovascular diseases and their complications. COPYRIGHT: (C)2010,JPO&INPIT