| 摘要 |
The invention is related to compounds of formula (I) as antagonists of the TGF&bgr; family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGF&bgr; family signaling activity is desirable.
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