CONTROL OF VIRAL-HOST MEMBRANE FUSION WITH HYDROGEN BOND SURROGATE-BASED ARTIFICIAL HELICES

摘要

The present invention relates to a peptide having one or more stable, internally-constrained HBS a- helices, where the peptide mimics at least a portion of a class I C-peptide helix or at least a portion of a class I N-peptide helix of a viral (e.g., HIV-I ) coiled-coil assembly. Methods of inhibiting viral infectivity of a subject by administering these peptides are also disclosed.