1-ADAMANTYLAZETIDIN-2-ONE DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME

摘要

Disclosed is a novel compound useful as a prophylactic and/or therapeutic agent for diseases associated with 11ß-hydroxysteroid dehydrogenase-1 (particularly diabetes, insulin resistance, diabetic complications, obesity, dyslipidemia, hypertension, fatty liver or metabolic syndrome). Specifically disclosed is a 1-adamantylazetidin-2-one derivative represented by general formula [wherein the ring A represents a C6-10 aryl group, or a 5- to 14-membered heteroaryl group; R1 represents a hydrogen atom, a halogen atom, a C1-6 alkoxycarbonyl group, a hydroxyl group, a carboxyl group, a carbamoyl group, or the like; R2 and R3 independently represent a C1-6 alkyl group; R4, R5 and R6 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, a C6-10 aryl group, or the like, or R4 and R5 or R5 and R6 may together form a C1-3 alkylenedioxy group; R7 and R8 independently represent a hydrogen atom, or a C1-6 alkyl group, or R7 and R8 may together form a C3-6 cyclic hydrocarbon group; and n represents an integer of 0 or 1], a salt of the derivative, or a solvate of the derivative or the salt.