发明名称 PURIFICATION OF BIOLOGICAL CONJUGATES BY SIZE EXCLUSION CHROMATOGRAPHY
摘要 A method for separating a biological conjugate from an aggregate. The molecular weight of the biological conjugate ranges from about 10 kDa to about 1000 kDa. In one embodiment, the method comprises the steps of: (e) providing a mixture comprising the biological conjugate and the aggregate, wherein the biological conjugate has a molecular weight of from about 10 kDa to about 1000 kDa; (f) providing a chromatography column containing a gel, wherein the gel comprises at least one polysaccharide; (g) introducing the mixture of step (a) into the chromatography column; (h) recovering the biological conjugate from the column.
申请公布号 US2010056766(A1) 申请公布日期 2010.03.04
申请号 US20080199047 申请日期 2008.08.27
申请人 ABBOTT LABORATORIES 发明人 DE LEON GATTI MARCELA;HUANG YINGQING;SCHISLA DAVID K.;SHEU LOU-HWA J.;TOMAS CHRISTOPHER A.
分类号 C07K1/00 主分类号 C07K1/00
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