Hematopoietic stem cells and methods of treatment of neovascular diseases therewith

摘要

Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin - HSCs) containing endothelial progenitor cells (EPCs) have been transfected with therapeutically useful genes. The transfected isolated stem cell populations of the invention are useful for delivering genes to the eye for cell-based gene therapy. Methods of preparing transfected isolated stem cell populations of the invention, and methods of treating ocular diseases and injury are also described.