| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for diagnosis of gastric cancer, a kit for diagnosis and a method for screening a candidate substance as a therapeutic agent for gastric cancer. <P>SOLUTION: It is found that in a gastric cancer cell strain the abnormal methylation of CpG island in an ACMG1 gene is observed with a high frequency and that the expression of the gene is suppressed. The invention discloses a method for detecting gastric cancer by determining the frequency of the methylation of an ACMG1 gene in a sample collected from a subject. It further discloses a method for screening a candidate substance as a therapeutic agent for gastric cancer by utilizing the suppression of the methylation of an ACMG1 gene or the promotion of the expression of an ACMG1 gene as an index. <P>COPYRIGHT: (C)2007,JPO&INPIT |
