发明名称 |
SOLID-PHASE FLUORINATION OF URACIL |
摘要 |
<p>The invention relates to a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-I+-TRACER (I) Y- wherein the TRACER is of formula (A): or an amine protected derivative thereof, wherein Y- is an anion, preferably trifluoromethylsulphonate (triflate) anion; and R1 is either (i) a group CH-NP1AP2A in which P1A and P2A are each independently hydrogen or a protecting group, or (ii) a carbonyl group; with 18F- to produce the labelled tracer of formula (II) or an amine protected derivative thereof, wherein R1 is as defined for the compound of formula (I).</p> |
申请公布号 |
EP1572249(B1) |
申请公布日期 |
2010.03.03 |
申请号 |
EP20030782657 |
申请日期 |
2003.12.19 |
申请人 |
HAMMERSMITH IMANET LIMITED |
发明人 |
BRADY, FRANK;LUTHRA, SAJINDER KAUR;ROBINS, EDWARD GEORGE |
分类号 |
A61K51/04;C07B59/00;C07D239/22 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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