发明名称 |
HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME |
摘要 |
<p>A process for obtaining a spray-dried high amylose sodium carboxymethyl starch comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA); dispersing the amorphous pregelatinized HASCA in a solution comprising water and at least one first pharmaceutically acceptable organic solvent miscible with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, in the form of a powder. Also provided is a spray-dried HASCA sustained-release excipient. This excipient is useful for preparing a tablet for the sustained-release of at least one drug.</p> |
申请公布号 |
EP2158223(A2) |
申请公布日期 |
2010.03.03 |
申请号 |
EP20080757221 |
申请日期 |
2008.06.05 |
申请人 |
UNIVERSITE DE MONTREAL |
发明人 |
BROUILLET, FABIEN;BATAILLE, BERNARD;BAYLAC, GILLES;CARTILIER, LOUIS |
分类号 |
C08B31/08;A61K9/22;A61K47/36;C08B30/06;C08B30/14;C08J3/12 |
主分类号 |
C08B31/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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