POLYPEPTIDE FOR INDUCING APOPTOSIS, DNA ENCODING SAME AND A PHARMACEUTICAL COMPOSITION FOR INDUCING APOPTOSIS CONTAINING SAME

摘要

PURPOSE: A polypeptide inducing apoptosis and a pharmaceutical composition for inducing apoptosis containing the same are provided to treat various cancers such as blood cancer and solid cancer. CONSTITUTION: A polypeptide Mcl-1ES BH3M inducing apoptosis is denoted by amino acid sequence 2. A DNA encoding the polypeptide is denoted by sequence number 1. The polypeptide Mcl-1ES BH3M is manufactured by mutating BH3 domain of splicing variant(Mcl-1ES) which a most portion of PEST domain is removed in McL-1L. A pharmaceutical composition for inducing apoptosis contains the polypeptide or the DNA encoding the same as an active ingredient.