PROSTAGLANDIN SYNTHESIS AND INTERMEDIATES FOR USE THEREIN

摘要

Fused cyclopentane - 4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: (see formula A) wherein R represents an aryl group such as p-methoxyphenyl. This compound can be reacted with a lower alkyl aluminum compound to open th e dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required .alpha.-side chain and then the required .omega.-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.