| 摘要 |
Disclosed is a pharmaceutical composition in unit dose form, wherein administration to a patient, the composition releases two or more amounts of a modafinil compound selected from modafinil and its individual enantiomers, wherein said composition comprises an effective amount of an immediate release formulation of said modafinil compound, and: a) a core particle comprising an effective amount of said modafinil compound; b) a membrane comprising an enteric polymer; c) a second membrane comprising a water-insoluble polymer and an enteric polymer wherein the water-insoluble polymer and the enteric polymer of the second membrane are present in the second membrane at a weight ratio of about 10:1 to 1:1; wherein the core particle is coated with the first and second membranes, in either order, to form an active drug particle, and the total weight of the first and second membranes is about 15 to 80 weight percent of the total weight of the active drug particle.
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