Treatment of inflammation, AB-induced cell toxicity, neuronal cell death or neuronal loss in subjects suffering from AlzheimerÆs disease

摘要

Disclosed is the use of an anionic compound, or a pharmaceutically acceptable salt thereof for the manufacture of a composition for the treatment or prevention of inflammation due to activation of macrophages by an amyloidogenic protein or peptide (such as soluble Amyloid-beta), or a functional fragment thereof; wherein said anionic compound has the structure: Q-[-Y-X+]n, where in Y is an anionic group at physiological pH (such as SO3); Q is a C3 aliphatic group; X+ is a cationic group; and n is an integer selected such that the biodistribution of the compound for an intended target site is not prevented while maintaining activity of said compound; with the proviso that said anionic compound is not 3-amino-1-propanesulfonic acid. Also disclosed is the above use, where the anionic compound is selected from the group consisting of 3-(cyclohexylamino)-1-propane sulfonate, 3-(N-morpholino)propanesulfonic acid.