1,2,1-Trifluoro-4-phenyl-4-methyl-2-(1H-pyrrolo[2,3-C]pyridin-2-ylmethyl)pentan-2-ol derivatives and related compounds as glucocorticoid ligands for the treatment of inflammatory diseases and diabetes.

摘要

Disclosed are compounds of Formula IA, IB, IC and ID wherein R1 is an optionally substituted aryl or heteroaryl group, R5 is an optionally substituted heteroaryl group and wherein the rest of the substituents are disclosed within the specification. Also disclosed is the preparation of a compound of formula IA, IB, IC or ID and the use of compound of formula IA, IB, IC and ID in the manufacture of a medicament for modulating glucocorticoid receptor function.