| 摘要 |
The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1):wherein Ris alkyl or aryl, and Ris alkyl, wherein alkyl refers to linear or branched alkyl group consisting of 1 to 8 carbon atoms, or cycloalkyl group consisting of 3 to 10 carbon atoms, aryl refers to aromatic groups, heteroaromatic groups and partially reduced derivatives thereof, said aromatic group refers to 5- to 15-membered unsaturated hydrocarbons in simple or fused cyclic form, and said heteroaromatic group refers to aromatic groups having 1 to 5 hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen fore use as caspase inhibitor, to a process for preparing it and to a pharmaceutical composition based thereon. |
