| 发明名称 |
METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES |
| 摘要 |
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
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| 申请公布号 |
US2010048872(A1) |
申请公布日期 |
2010.02.25 |
| 申请号 |
US20090604165 |
申请日期 |
2009.10.22 |
| 申请人 |
BOLDER BIOTECHNOLOGY, INC. |
发明人 |
COX, III GEORGE N.;DOHERTY DANIEL H.;ROSENDAHL MARY S. |
| 分类号 |
C07K14/56;A61K47/48;C07K1/113;C07K14/505;C07K14/61;C07K14/72;C12P21/02 |
主分类号 |
C07K14/56 |
| 代理机构 |
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