| 摘要 |
A contrast agent for enhancing contrast in in vivo magnetic resonance imaging, comprising a water-soluble, non-zero spin isotope-enriched substituted fullerene having a fullerene core or heterofullerene core and at least one substituent group bonded to at least one carbon of the fullerene core. A method of magnetic resonance imaging a sample, comprising (i) administering to the sample a plurality of substituted fullerenes; and (ii) detecting magnetic resonance signals from the sample. In the method, some or all of the plurality of substituted fullerenes may be non-zero spin isotope-enriched, but need not be. In the method, some or all of the plurality of substituted fullerenes may be hyperpolarized, but need not be. |
