发明名称 |
COMPOSITIONS AND PROCESSES RELATING TO HUMAN BOCAVIRUS |
摘要 |
Non-replicating, antigenic, human bocavirus virus-like particles (HBoV VLPs) are provided by the present invention along with assays using the HBoV VLPs to detect anti-HBoV antibodies in a biological sample. Pharmaceutical compositions including HBoV VLPs and/or anti-HBoV antibodies are described herein along with novel antibodies generated using HBoV VLPs as an antigen. A recombinant baculovirus is provided including a DNA sequence encoding an expressible human bocavirus VP2 with or without a DNA sequence encoding an expressible human bocavirus VPl polypeptide, and/or a non-HBoV peptide or protein, and culturing the cells to form the VPl and/or VP2 proteins that self assemble to form the HBoV VLPs which are then amenable to isolation. |
申请公布号 |
WO2009151697(A3) |
申请公布日期 |
2010.02.25 |
申请号 |
WO2009US37142 |
申请日期 |
2009.03.13 |
申请人 |
THE GOVERNMENT OF UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;ERDMAN, DEAN, D.;PERET, TERESA |
发明人 |
ERDMAN, DEAN, D.;PERET, TERESA |
分类号 |
C12N7/00;A61K39/12;C12N15/33;C12N15/63;G01N33/53;G01N33/569 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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