PRODUCTION OF N-ACYLATED SULPHUR-CONTAINING AMINO ACIDS WITH MICROORGANISMS HAVING ENHANCED N-ACYLTRANSFERASE ENZYMATIC ACTIVITY

摘要

The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferaseenzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.