发明名称 |
Marked bovine viral diarrhea virus vaccines |
摘要 |
<p>The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.</p> |
申请公布号 |
AU2006323028(B2) |
申请公布日期 |
2010.02.25 |
申请号 |
AU20060323028 |
申请日期 |
2006.11.24 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
GABRIELE ZYBARTH;CHICHI HUANG;XUEMEI CAO;MICHAEL G. SHEPPARD |
分类号 |
A61K39/12;C07K14/18;C12N7/04 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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