发明名称 |
Anti-Tumor Antibodies |
摘要 |
Chondroition sulfate proteoglycans represent excellent targets for anti-tumor immunotherapy. Antibodies which target such proteoglycans can be used alone, in combinations, armed with a cytotoxic payload or unarmed. Combinations of such antibodies can target different epitopes of the proteoglycans. Internalization of the antibodies can increase the toxicity of the payloads. Single chain variable regions are especially advantageous for such anti-tumor immunotherapy.
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申请公布号 |
US2010047164(A1) |
申请公布日期 |
2010.02.25 |
申请号 |
US20090418956 |
申请日期 |
2009.04.06 |
申请人 |
DUKE UNIVERSITY;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE;SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
BIGNER DARELL;KUAN CHIEN-TSUN;PASTAN IRA H.;REISFELD RALPH |
分类号 |
A61K51/00;A61K39/395;C07K16/00;G01N33/574 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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地址 |
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