SCALABLE CELL CULTURE BIOREACTOR AND CELL CULTURE PROCESS

摘要

The present invention relates to a scaleable bioreactor comprising at least one cassette comprising a manifold and an arrangement of hollow fibre membranes; an upper headplate; and a lower headplate, wherein the cassette(s) are modular components adapted to co-operate with each other and the headplates to define an internal extracapillary culture space (ECS) and wherein the arrangement of hollow fibre membranes includes a discrete inlet and outlet. The invention further relates to a kit for such a bioreactor, a cassette for ue in such a bioreactor and a process for exploiting the metabolism of cells and/or microorganisms, the process including the step of utilising a bioreactor according to the invention.